MGP Database

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MGP002462

UniProt Annotations

Entry Information
Gene Nameprotease, serine, 3
Protein EntryTRY3_HUMAN
UniProt IDP35030
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=A; IsoId=P35030-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P35030-2; Sequence=VSP_042074; Name=3; Synonyms=C; IsoId=P35030-3; Sequence=VSP_005410; Name=4; Synonyms=D; IsoId=P35030-4; Sequence=VSP_005409; Name=5; Synonyms=E; IsoId=P35030-5; Sequence=VSP_053779;
Catalytic ActivityPreferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
FunctionDigestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:14507909}.
SimilarityBelongs to the peptidase S1 family. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
Subcellular LocationSecreted.
Tissue SpecificityExpressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269|PubMed:12021776}.
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