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MGP002464

Record overview

MGPD IDMGP002464
Gene ID5650
SpeciesHomo sapiens (Human)
Gene Namekallikrein-related peptidase 7
Gene Symbol KLK7
SynonymshK7; SCCE; PRSS6;
Alternate nameskallikrein-7; kallikrein 7 (chymotryptic, stratum corneum); serine protease 6; signal protein; stratum corneum chymotryptic enzyme;
Chromosome19
Map Location19q13.41
EC Number3.4.21.117
SummaryThis gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
OrthologsView orthologs and multiple alignments for KLK7

Proteins

kallikrein-7 isoform 1 preproprotein
Refseq ID:NP_644806
Protein GI:21327705
UniProt ID:P49862
mRNA ID:NM_139277
Length:253
RefSeq Status:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFR
HPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNA
CNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
 
sig_peptide: 1..22
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 2337
peptide sequence: 
MARSLLLPLQILLLSLALETAG

mat_peptide: 30..253
product: Kallikrein-7
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 24448
peptide sequence: 
IIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVK
KVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQP
NDPGVYTQVCKFTKWINDTMKKHR
 
kallikrein-7 isoform 1 preproprotein
Refseq ID:NP_005037
Protein GI:4826950
UniProt ID:P49862
mRNA ID:NM_005046
Length:253
RefSeq Status:
Protein sequence is identical to GI:21327705 (mRNA isoform)
 
sig_peptide: 1..22
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 2337
peptide sequence: 
MARSLLLPLQILLLSLALETAG

mat_peptide: 30..253
product: Kallikrein-7
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 24448
peptide sequence: 
IIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVK
KVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQP
NDPGVYTQVCKFTKWINDTMKKHR

sig_peptide: 1..22
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 2337
peptide sequence: 
MARSLLLPLQILLLSLALETAG

mat_peptide: 30..253
product: Kallikrein-7
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 24448
peptide sequence: 
IIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVK
KVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQP
NDPGVYTQVCKFTKWINDTMKKHR
 
kallikrein-7 isoform 2
Refseq ID:NP_001193982
Protein GI:333609286
UniProt ID:P49862
mRNA ID:NM_001207053
Length:181
RefSeq Status:
MNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLIS
PQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
 
sig_peptide: 1..22
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 2337
peptide sequence: 
MARSLLLPLQILLLSLALETAG

mat_peptide: 30..253
product: Kallikrein-7
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 24448
peptide sequence: 
IIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVK
KVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQP
NDPGVYTQVCKFTKWINDTMKKHR
 
kallikrein-7 isoform 3
Refseq ID:NP_001230055
Protein GI:341823646
UniProt ID:P49862
mRNA ID:NM_001243126
Length:246
RefSeq Status:
MKILEPSCVPAQVGTWITSDPLELQQERPFLAWQPLSGSAGHHGKIPSPAPADLTAILSLGNCRRRSEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQ
THVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGG
PLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
 
sig_peptide: 1..22
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 2337
peptide sequence: 
MARSLLLPLQILLLSLALETAG

mat_peptide: 30..253
product: Kallikrein-7
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49862.1)
calculated_mol_wt: 24448
peptide sequence: 
IIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVK
KVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQP
NDPGVYTQVCKFTKWINDTMKKHR
 
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