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MGP002464

UniProt Annotations

Entry Information

Gene Name	kallikrein-related peptidase 7
Protein Entry	KLK7_HUMAN
UniProt ID	P49862
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P49862-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P49862-2; Sequence=VSP_013581;
Catalytic Activity	Cleavage of proteins with aromatic side chains in the P1 position.
Enzyme Regulation	Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12. {ECO:0000269\|PubMed:23370777}.
Function	May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-\|-Gln-15' and insulin B chain at '6- Leu-\|-Cys-7', '16-Tyr-\|-Leu-17', '25-Phe-\|-Tyr-26' and '26-Tyr-\|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269\|PubMed:23370777}.
Induction	By estrogens and glucocorticoids in a breast carcinoma cell line. {ECO:0000269\|PubMed:10974542}.
Similarity	Belongs to the peptidase S1 family. Kallikrein subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00274}.
Similarity	Contains 1 peptidase S1 domain. {ECO:0000255\|PROSITE- ProRule:PRU00274}.
Subcellular Location	Secreted {ECO:0000269\|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
Tissue Specificity	Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269\|PubMed:10974542, ECO:0000269\|PubMed:12738725}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/KLK7ID41087ch19q13.html";