MGP Database

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MGP002494

Ontology/Pathway Information

Entrez Gene ID5708
Gene Nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Gene Symbol PSMD2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0022624 ISS:UniProtKBCproteasome accessory complex
GO:0000502 IDA:UniProtKBCproteasome complex
GO:0005838 TAS:ProtIncCproteasome regulatory particle
GO:0030234 IEA:InterProFenzyme regulator activity
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474 TAS:ReactomePantigen processing and presentation of peptide antigen via MHC class I
GO:0006915 TAS:ReactomePapoptotic process
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0006977 TAS:ReactomePDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0010467 TAS:ReactomePgene expression
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0043066 TAS:ReactomePnegative regulation of apoptotic process
GO:0051436 TAS:ReactomePnegative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS:ReactomePpositive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0000209 TAS:ReactomePprotein polyubiquitination
GO:0042981 TAS:ReactomePregulation of apoptotic process
GO:0006521 TAS:ReactomePregulation of cellular amino acid metabolic process
GO:0042176 IEA:InterProPregulation of protein catabolic process
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0016032 TAS:ReactomePviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_118656Activation of NF-kappaB in B cells
REACT_75774Adaptive Immune System
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_111119Antigen processing-Cross presentation
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_6871APC/C:Cdc20 mediated degradation of Securin
REACT_6761APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
REACT_267701APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_578Apoptosis
REACT_2243Assembly of the pre-replicative complex
REACT_264478Asymmetric localization of PCP proteins
REACT_25325AUF1 (hnRNP D0) destabilizes mRNA
REACT_6785Autodegradation of Cdh1 by Cdh1:APC/C
REACT_20549Autodegradation of the E3 ubiquitin ligase COP1
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_264224beta-catenin independent WNT signaling
REACT_6850Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT_1221CDK-mediated phosphorylation and removal of Cdc6
REACT_1949CDT1 association with the CDC6:ORC:origin complex
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_111056Cross-presentation of soluble exogenous antigens (endosomes)
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_1574Cyclin E associated events during G1/S transition
REACT_263873degradation of AXIN
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_264438degradation of DVL
REACT_268156Degradation of GLI1 by the proteasome
REACT_267700Degradation of GLI2 by the proteasome
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_116125Disease
REACT_383DNA Replication
REACT_734DNA Replication Pre-Initiation
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_111178ER-Phagosome pathway
REACT_2254G1/S DNA Damage Checkpoints
REACT_1783G1/S Transition
REACT_71Gene Expression
REACT_268366GLI3 is processed to GLI3R by the proteasome
REACT_264605Hedgehog ligand biogenesis
REACT_268323Hedgehog 'off' state
REACT_268718Hedgehog 'on' state
REACT_263883Hh ligand biogenesis disease
REACT_6185HIV Infection
REACT_6288Host Interactions of HIV factors
REACT_6900Immune System
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_1725M/G1 Transition
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_1275Mitotic Anaphase
REACT_21267Mitotic G1-G1/S phases
REACT_150314Mitotic Metaphase and Anaphase
REACT_910M Phase
REACT_1156Orc1 removal from chromatin
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_2160p53-Independent DNA Damage Response
REACT_1208p53-Independent G1/S DNA damage checkpoint
REACT_264199PCP/CE pathway
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_264623Processing-defective Hh variants abrogate ligand secretion
REACT_268456Programmed Cell Death
REACT_13464Regulation of activated PAK-2p34 by proteasome mediated degradation
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_13648Regulation of Apoptosis
REACT_829Regulation of DNA replication
REACT_21279Regulation of mitotic cell cycle
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_13565Regulation of ornithine decarboxylase (ODC)
REACT_207Removal of licensing factors from origins
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_6821SCF-beta-TrCP mediated degradation of Emi1
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_150471Separation of Sister Chromatids
REACT_264508Signaling by Hedgehog
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_899S Phase
REACT_309Stabilization of p53
REACT_2148Switching of origins to a post-replicative state
REACT_2014Synthesis of DNA
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_938Ubiquitin-dependent degradation of Cyclin D
REACT_4Ubiquitin-dependent degradation of Cyclin D1
REACT_1614Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
REACT_9453Vif-mediated degradation of APOBEC3G
REACT_9031Vpu mediated degradation of CD4
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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