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MGP002494

UniProt Annotations

Entry Information
Gene Nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Protein EntryPSMD2_HUMAN
UniProt IDQ13200
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13200-1; Sequence=Displayed; Name=2; IsoId=Q13200-2; Sequence=VSP_055065; Note=No experimental confirmation available.; Name=3; IsoId=Q13200-3; Sequence=VSP_055066; Note=No experimental confirmation available.;
FunctionActs as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
FunctionBinds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
InteractionQ53HB3:-; NbExp=2; IntAct=EBI-357648, EBI-9362707; Q99933:BAG1; NbExp=2; IntAct=EBI-357648, EBI-1030678; Q8AZK7:EBNA-LP (xeno); NbExp=2; IntAct=EBI-357648, EBI-1185167; P58340:MLF1; NbExp=2; IntAct=EBI-357648, EBI-721328; P62191:PSMC1; NbExp=6; IntAct=EBI-357648, EBI-357598; P62195:PSMC5; NbExp=9; IntAct=EBI-357648, EBI-357745; P55036:PSMD4; NbExp=3; IntAct=EBI-357648, EBI-359318; Q8K2C9:ptplad1 (xeno); NbExp=2; IntAct=EBI-357648, EBI-8329978; Q9Y5K5:UCHL5; NbExp=5; IntAct=EBI-357648, EBI-1051183;
Sequence CautionSequence=AAA87705.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the proteasome subunit S2 family. {ECO:0000305}.
SimilarityContains 7 PC repeats. {ECO:0000305}.
Tissue SpecificityFound in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
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