MGP Database

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MGP002502

UniProt Annotations

Entry Information
Gene Nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Protein EntryPSD11_HUMAN
UniProt IDO00231
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00231-1; Sequence=Displayed; Name=2; IsoId=O00231-2; Sequence=VSP_044400; Note=No experimental confirmation available.;
FunctionComponent of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:22972301}.
InductionBy FOXO4; expression in embryonic stem cells (ESCs) is mediated by FOXO4. {ECO:0000269|PubMed:22972301}.
InteractionQ96LA8:PRMT6; NbExp=2; IntAct=EBI-357816, EBI-912440;
PtmPhosphorylated by AMPK. {ECO:0000269|PubMed:17323924, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19616115}.
SimilarityBelongs to the proteasome subunit S9 family. {ECO:0000305}.
SimilarityContains 1 PCI domain. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
SubunitComponent of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. {ECO:0000269|PubMed:22972301}.
Tissue SpecificityHighly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. {ECO:0000269|PubMed:22972301}.
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