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MGP002506

UniProt Annotations

Entry Information
Gene Namephosphoserine phosphatase
Protein EntrySERB_HUMAN
UniProt IDP78330
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityO-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate. {ECO:0000269|PubMed:12213811, ECO:0000269|PubMed:12777757, ECO:0000269|PubMed:15291819}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15291819}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000269|PubMed:15291819};
DiseasePhosphoserine phosphatase deficiency (PSPHD) [MIM:614023]: A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. {ECO:0000269|PubMed:14673469}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Enzyme RegulationInhibited by calcium ions. {ECO:0000269|PubMed:15291819}.
FunctionCatalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. {ECO:0000269|PubMed:12777757}.
InteractionQ9NVP2:ASF1B; NbExp=1; IntAct=EBI-1042956, EBI-1055650; Q14558:PRPSAP1; NbExp=1; IntAct=EBI-1042956, EBI-724449; Q9Y6J8:STYXL1; NbExp=1; IntAct=EBI-1042956, EBI-1044511;
PathwayAmino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
SimilarityBelongs to the SerB family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:12213811, ECO:0000269|PubMed:12777757, ECO:0000269|PubMed:15291819}.
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