MGP Database

MGP002517

Ontology/Pathway Information

Entrez Gene ID	5734
Gene Name	prostaglandin E receptor 4 (subtype EP4)
Gene Symbol	PTGER4
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016021	NAS:UniProtKB	C	integral component of membrane
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0004957	IDA:UniProtKB	F	prostaglandin E receptor activity
GO:0007188	IDA:UniProtKB	P	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0060348	ISS:UniProtKB	P	bone development
GO:0071260	ISS:UniProtKB	P	cellular response to mechanical stimulus
GO:0070371	ISS:UniProtKB	P	ERK1 and ERK2 cascade
GO:0006955	IEP:UniProtKB	P	immune response
GO:0007254	ISS:UniProtKB	P	JNK cascade
GO:0050710	ISS:UniProtKB	P	negative regulation of cytokine secretion
GO:2000420	IDA:UniProtKB	P	negative regulation of eosinophil extravasation
GO:0050728	IDA:UniProtKB	P	negative regulation of inflammatory response
GO:0033624	IDA:UniProtKB	P	negative regulation of integrin activation
GO:0050715	ISS:UniProtKB	P	positive regulation of cytokine secretion
GO:0050729	ISS:UniProtKB	P	positive regulation of inflammatory response
GO:0030278	IEA:Ensembl	P	regulation of ossification
GO:0051492	ISS:UniProtKB	P	regulation of stress fiber assembly
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0009612	IEP:UniProtKB	P	response to mechanical stimulus
GO:0042093	ISS:UniProtKB	P	T-helper cell differentiation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_18352	Eicosanoid ligand-binding receptors
REACT_19327	G alpha (s) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_18425	Prostanoid ligand receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction