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MGP002517

UniProt Annotations

Entry Information
Gene Nameprostaglandin E receptor 4 (subtype EP4)
Protein EntryPE2R4_HUMAN
UniProt IDP35408
SpeciesHuman
Comments
Comment typeDescription
CautionWas originally designated as the EP2 subtype. {ECO:0000305}.
FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
PtmPhosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. {ECO:0000269|PubMed:11597569, ECO:0000269|PubMed:14709160}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with FEM1A. {ECO:0000269|PubMed:16424369}.
Tissue SpecificityHigh in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ptger4/";
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