MGP Database

MGP002520

Record overview

MGPD ID	MGP002520
Gene ID	5740
Species	Homo sapiens (Human)
Gene Name	prostaglandin I2 (prostacyclin) synthase
Gene Symbol	PTGIS
Synonyms	CYP8; PGIS; PTGI; CYP8A1;
Alternate names	prostacyclin synthase; cytochrome P450, family 8, subfamily A, polypeptide 1; prostaglandin I2 synthase;
Chromosome	20
Map Location	20q13.13
EC Number	5.3.99.4
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for PTGIS

Proteins

prostacyclin synthase precursor

Refseq ID:	NP_000952
Protein GI:	13699859
UniProt ID:	Q16647
mRNA ID:	NM_000961
Length:	500
RefSeq Status:

MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYA
IFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHS
ADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTD
PEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

`sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2649 peptide sequence: MAWAALLGLLAALLLLLLLSRRRT`