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MGP002520

UniProt Annotations

Entry Information
Gene Nameprostaglandin I2 (prostacyclin) synthase
Protein EntryPTGIS_HUMAN
UniProt IDQ16647
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11- alpha,15-dihydroxyprosta-5,13-dienoate.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:17020766};
FunctionCatalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein.
Tissue SpecificityWidely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTGISID44219ch20q13.html";
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP8A1 alleles; URL="http://www.cypalleles.ki.se/cyp8a1.htm";
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