MGP Database

MGP002524

Record overview

MGPD ID	MGP002524
Gene ID	5744
Species	Homo sapiens (Human)
Gene Name	parathyroid hormone-like hormone
Gene Symbol	PTHLH
Synonyms	HHM; PLP; BDE2; PTHR; PTHRP;
Alternate names	parathyroid hormone-related protein; PTH-rP; PTH-related protein; osteostatin; parathyroid hormone-like hormone preproprotein; parathyroid hormone-like related protein;
Chromosome	12
Map Location	12p12.1-p11.2
Summary	The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]
Orthologs	View orthologs and multiple alignments for PTHLH

Proteins

parathyroid hormone-related protein isoform 1 preproprotein

Refseq ID:	NP_945316
Protein GI:	39995091
UniProt ID:	P12272
mRNA ID:	NM_198965
Length:	177
RefSeq Status:

`MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDE GRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH`

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..175
product: parathyroid hormone-related protein isoform 2
calculated_mol_wt: 15741
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..175
product: parathyroid hormone-related protein isoform 2
calculated_mol_wt: 15741
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..177
product: parathyroid hormone-related protein isoform 1
calculated_mol_wt: 16034
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH

parathyroid hormone-related protein isoform 1 preproprotein

Refseq ID:	NP_945317
Protein GI:	39995093
UniProt ID:	P12272
mRNA ID:	NM_198966
Length:	177
RefSeq Status:

Protein sequence is identical to GI:39995091 (mRNA isoform)

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..175
product: parathyroid hormone-related protein isoform 2
calculated_mol_wt: 15741
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..175
product: parathyroid hormone-related protein isoform 2
calculated_mol_wt: 15741
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..177
product: parathyroid hormone-related protein isoform 1
calculated_mol_wt: 16034
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..177
product: parathyroid hormone-related protein isoform 1
calculated_mol_wt: 16034
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH

parathyroid hormone-related protein isoform 2 preproprotein

Refseq ID:	NP_945315
Protein GI:	39995089
UniProt ID:	P12272
mRNA ID:	NM_198964
Length:	175
RefSeq Status:

`MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDE GRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR`

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..175
product: parathyroid hormone-related protein isoform 2
calculated_mol_wt: 15741
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..175
product: parathyroid hormone-related protein isoform 2
calculated_mol_wt: 15741
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR

parathyroid hormone-related protein isoform 2 preproprotein

Refseq ID:	NP_002811
Protein GI:	4506269
UniProt ID:	P12272
mRNA ID:	NM_002820
Length:	175
RefSeq Status:

Protein sequence is identical to GI:39995089 (mRNA isoform)

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2739
peptide sequence: 
MQRRLVQQWSVAVFLLSYAVPSCG

mat_peptide: 37..175
product: parathyroid hormone-related protein isoform 2
calculated_mol_wt: 15741
peptide sequence: 
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQ
EKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR