MGP Database

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MGP002528

Ontology/Pathway Information

Entrez Gene ID5770
Gene Nameprotein tyrosine phosphatase, non-receptor type 1
Gene Symbol PTPN1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031410 IEA:EnsemblCcytoplasmic vesicle
GO:0005829 TAS:ReactomeCcytosol
GO:0005769 IDA:UniProtKBCearly endosome
GO:0005783 IDA:HPACendoplasmic reticulum
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0097443 ISS:BHF-UCLCsorting endosome
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0046875 IPI:UniProtKBFephrin receptor binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004725 IDA:UniProtKBFprotein tyrosine phosphatase activity
GO:0030971 IPI:UniProtKBFreceptor tyrosine kinase binding
GO:0008270 IDA:UniProtKBFzinc ion binding
GO:0031532 IMP:UniProtKBPactin cytoskeleton reorganization
GO:0007596 TAS:ReactomePblood coagulation
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0030968 IDA:UniProtKBPendoplasmic reticulum unfolded protein response
GO:0008286 IEA:EnsemblPinsulin receptor signaling pathway
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0070373 ISS:BHF-UCLPnegative regulation of ERK1 and ERK2 cascade
GO:0046627 NAS:BHF-UCLPnegative regulation of insulin receptor signaling pathway
GO:0030948 ISS:BHF-UCLPnegative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035335 IDA:UniProtKBPpeptidyl-tyrosine dephosphorylation
GO:1990264 ISS:BHF-UCLPpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:0030168 TAS:ReactomePplatelet activation
GO:0035791 IMP:UniProtKBPplatelet-derived growth factor receptor-beta signaling pathway
GO:0030100 IDA:UniProtKBPregulation of endocytosis
GO:1902202 IMP:UniProtKBPregulation of hepatocyte growth factor receptor signaling pathway
GO:0060334 TAS:ReactomePregulation of interferon-gamma-mediated signaling pathway
GO:0009966 IMP:UniProtKBPregulation of signal transduction
GO:0060338 TAS:ReactomePregulation of type I interferon-mediated signaling pathway
GO:0060337 TAS:ReactomePtype I interferon signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75790Cytokine Signaling in Immune system
REACT_111133Growth hormone receptor signaling
REACT_604Hemostasis
REACT_6900Immune System
REACT_15523Integrin alphaIIb beta3 signaling
REACT_25162Interferon alpha/beta signaling
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_25216Regulation of IFNA signaling
REACT_24980Regulation of IFNG signaling
REACT_111102Signal Transduction
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