MGP Database

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MGP002528

UniProt Annotations

Entry Information
Gene Nameprotein tyrosine phosphatase, non-receptor type 1
Protein EntryPTN1_HUMAN
UniProt IDP18031
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
FunctionTyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
InteractionP56945:BCAR1; NbExp=5; IntAct=EBI-968788, EBI-702093; Q61140:Bcar1 (xeno); NbExp=5; IntAct=EBI-968788, EBI-77088; Q63767:Bcar1 (xeno); NbExp=5; IntAct=EBI-968788, EBI-1176801; P11274-1:BCR; NbExp=3; IntAct=EBI-968788, EBI-8658094; P07384:CAPN1; NbExp=4; IntAct=EBI-968788, EBI-1542113; Q03135:CAV1; NbExp=5; IntAct=EBI-968788, EBI-603614; P15116:Cdh2 (xeno); NbExp=3; IntAct=EBI-968788, EBI-397974; Q63768:Crk (xeno); NbExp=2; IntAct=EBI-968788, EBI-8423843; Q14247:CTTN; NbExp=2; IntAct=EBI-968788, EBI-351886; P00533:EGFR; NbExp=6; IntAct=EBI-968788, EBI-297353; P19235:EPOR; NbExp=3; IntAct=EBI-968788, EBI-617321; P10912:GHR; NbExp=5; IntAct=EBI-968788, EBI-286316; P62993:GRB2; NbExp=2; IntAct=EBI-968788, EBI-401755; P62994:Grb2 (xeno); NbExp=3; IntAct=EBI-968788, EBI-401775; P08069:IGF1R; NbExp=3; IntAct=EBI-968788, EBI-475981; P06213:INSR; NbExp=33; IntAct=EBI-968788, EBI-475899; P35570:Irs1 (xeno); NbExp=3; IntAct=EBI-968788, EBI-520230; P05556:ITGB1; NbExp=2; IntAct=EBI-968788, EBI-703066; P05106:ITGB3; NbExp=4; IntAct=EBI-968788, EBI-702847; O60674:JAK2; NbExp=5; IntAct=EBI-968788, EBI-518647; O43561:LAT; NbExp=3; IntAct=EBI-968788, EBI-1222766; P08581:MET; NbExp=3; IntAct=EBI-968788, EBI-1039152; P04629:NTRK1; NbExp=2; IntAct=EBI-968788, EBI-1028226; P09619:PDGFRB; NbExp=3; IntAct=EBI-968788, EBI-641237; P05622:Pdgfrb (xeno); NbExp=3; IntAct=EBI-968788, EBI-1554855; P10686:Plcg1 (xeno); NbExp=4; IntAct=EBI-968788, EBI-520788; P34152:Ptk2 (xeno); NbExp=2; IntAct=EBI-968788, EBI-77070; Q8VI36:Pxn (xeno); NbExp=2; IntAct=EBI-968788, EBI-983394; P08922:ROS1; NbExp=3; IntAct=EBI-968788, EBI-7371065; P12931:SRC; NbExp=14; IntAct=EBI-968788, EBI-621482; P40763:STAT3; NbExp=2; IntAct=EBI-968788, EBI-518675; P42229:STAT5A; NbExp=2; IntAct=EBI-968788, EBI-749537; P63166:Sumo1 (xeno); NbExp=2; IntAct=EBI-968788, EBI-80152; Q9H1D0:TRPV6; NbExp=6; IntAct=EBI-968788, EBI-7198335; P10599:TXN; NbExp=2; IntAct=EBI-968788, EBI-594644;
PtmOxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. {ECO:0000269|PubMed:12802338, ECO:0000269|PubMed:12802339}.
PtmSer-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:11579209, ECO:0000269|PubMed:15592455, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:8491187, ECO:0000269|PubMed:9355745}.
PtmS-nitrosylation of Cys-215 inactivates the enzyme activity. {ECO:0000269|PubMed:22169477}.
PtmSulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. {ECO:0000305}.
SimilarityContains 1 tyrosine-protein phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU00160}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
SubunitInteracts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts with MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTPN1ID41909ch20q13.html";
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