MGP Database

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MGP002529

Ontology/Pathway Information

Entrez Gene ID5777
Gene Nameprotein tyrosine phosphatase, non-receptor type 6
Gene Symbol PTPN6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0042105 IEA:EnsemblCalpha-beta T cell receptor complex
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 TAS:ProtIncCmembrane
GO:0005730 IDA:HPACnucleolus
GO:0005634 IDA:BHF-UCLCnucleus
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004725 TAS:ReactomeFprotein tyrosine phosphatase activity
GO:0005001 IDA:UniProtKBFtransmembrane receptor protein tyrosine phosphatase activity
GO:0033277 IEA:EnsemblPabortive mitotic cell cycle
GO:0006915 TAS:ProtIncPapoptotic process
GO:0050853 IEA:EnsemblPB cell receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0030154 IDA:UniProtKBPcell differentiation
GO:0008283 IDA:UniProtKBPcell proliferation
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0007186 TAS:ProtIncPG-protein coupled receptor signaling pathway
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0050900 TAS:ReactomePleukocyte migration
GO:0035855 IEA:EnsemblPmegakaryocyte development
GO:0042267 IEA:EnsemblPnatural killer cell mediated cytotoxicity
GO:0050859 IEA:EnsemblPnegative regulation of B cell receptor signaling pathway
GO:0008285 NAS:UniProtKBPnegative regulation of cell proliferation
GO:0002924 IEA:EnsemblPnegative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043407 IEA:EnsemblPnegative regulation of MAP kinase activity
GO:0050732 IMP:BHF-UCLPnegative regulation of peptidyl-tyrosine phosphorylation
GO:0042130 IEA:EnsemblPnegative regulation of T cell proliferation
GO:0050860 IEA:EnsemblPnegative regulation of T cell receptor signaling pathway
GO:0035335 IDA:GOCPpeptidyl-tyrosine dephosphorylation
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0070527 IEA:EnsemblPplatelet aggregation
GO:0030220 IEA:EnsemblPplatelet formation
GO:0033630 IEA:EnsemblPpositive regulation of cell adhesion mediated by integrin
GO:0008284 IMP:BHF-UCLPpositive regulation of cell proliferation
GO:0014068 IMP:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0006470 IDA:UniProtKBPprotein dephosphorylation
GO:0045577 IEA:EnsemblPregulation of B cell differentiation
GO:0070372 IDA:UniProtKBPregulation of ERK1 and ERK2 cascade
GO:2000045 IMP:BHF-UCLPregulation of G1/S transition of mitotic cell cycle
GO:0060334 TAS:ReactomePregulation of interferon-gamma-mediated signaling pathway
GO:0051279 IEA:EnsemblPregulation of release of sequestered calcium ion into cytosol
GO:0060338 TAS:ReactomePregulation of type I interferon-mediated signaling pathway
GO:0031295 TAS:ReactomePT cell costimulation
GO:0060337 TAS:ReactomePtype I interferon signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_111155Cell-Cell communication
REACT_12051Cell surface interactions at the vascular wall
REACT_19344Costimulation by the CD28 family
REACT_75790Cytokine Signaling in Immune system
REACT_111133Growth hormone receptor signaling
REACT_604Hemostasis
REACT_6900Immune System
REACT_25162Interferon alpha/beta signaling
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_19324PD-1 signaling
REACT_12519PECAM1 interactions
REACT_23876Platelet homeostasis
REACT_23879Platelet sensitization by LDL
REACT_25216Regulation of IFNA signaling
REACT_24980Regulation of IFNG signaling
REACT_111225Regulation of KIT signaling
REACT_22232Signaling by Interleukins
REACT_111040Signaling by SCF-KIT
REACT_23916Signal regulatory protein (SIRP) family interactions
REACT_111102Signal Transduction
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