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MGP002529

UniProt Annotations

Entry Information
Gene Nameprotein tyrosine phosphatase, non-receptor type 6
Protein EntryPTN6_HUMAN
UniProt IDP29350
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long; IsoId=P29350-1; Sequence=Displayed; Name=2; IsoId=P29350-3; Sequence=VSP_007775; Name=3; Synonyms=Short; IsoId=P29350-2; Sequence=VSP_005129, VSP_005130; Name=4; Synonyms=70-kDa, SHP-1L; IsoId=P29350-4; Sequence=VSP_044447;
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
DomainThe N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation. {ECO:0000269|PubMed:12482860, ECO:0000269|PubMed:21465528}.
FunctionModulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:11266449}.
InteractionQ14790:CASP8; NbExp=3; IntAct=EBI-78260, EBI-78060; P20273:CD22; NbExp=4; IntAct=EBI-78260, EBI-78277; P20138:CD33; NbExp=8; IntAct=EBI-78260, EBI-3906571; P11049:CD37; NbExp=4; IntAct=EBI-78260, EBI-6139068; P19235:EPOR; NbExp=11; IntAct=EBI-78260, EBI-617321; P31994:FCGR2B; NbExp=3; IntAct=EBI-78260, EBI-724784; P43626:KIR2DL1; NbExp=4; IntAct=EBI-78260, EBI-8684277; P43628:KIR2DL3; NbExp=13; IntAct=EBI-78260, EBI-8632435; Q6GTX8:LAIR1; NbExp=5; IntAct=EBI-78260, EBI-965864; P06239:LCK; NbExp=5; IntAct=EBI-78260, EBI-1348; P16284:PECAM1; NbExp=4; IntAct=EBI-78260, EBI-716404; Q9UKJ1:PILRA; NbExp=5; IntAct=EBI-78260, EBI-965833; P08922:ROS1; NbExp=2; IntAct=EBI-78260, EBI-7371065; B7UM99:tir (xeno); NbExp=4; IntAct=EBI-78260, EBI-2504426; Q7DB77:tir (xeno); NbExp=2; IntAct=EBI-78260, EBI-6480811;
PtmPhosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity. {ECO:0000250, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:7781604}.
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. {ECO:0000305}.
SimilarityContains 1 tyrosine-protein phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU00160}.
SimilarityContains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.
SubunitMonomer. Interacts with MTUS1 (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Interacts with KIT (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, FCRL3, FCRL4, CD300LF, CDK2 and CD84. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts (via SH2 1 domain) with ROS1; the interaction is direct and promotes ROS1 dephosphorylation. Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with LYN. Interacts with the tyrosine phosphorylated form of PDPK1. {ECO:0000250, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11162587, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11414741, ECO:0000269|PubMed:14597715, ECO:0000269|PubMed:15184070, ECO:0000269|PubMed:18604210, ECO:0000269|PubMed:19591923, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9712903, ECO:0000269|PubMed:9842885}.
Tissue SpecificityIsoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTPN6ID41920ch12p13.html";
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