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MGP002543

Record overview

MGPD IDMGP002543
Gene ID5831
SpeciesHomo sapiens (Human)
Gene Namepyrroline-5-carboxylate reductase 1
Gene Symbol PYCR1
SynonymsP5C; P5CR; PRO3; PYCR; PIG45; PP222; ARCL2B; ARCL3B;
Alternate namespyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; proliferation-inducing protein 45;
Chromosome17
Map Location17q25.3
EC Number1.5.1.2;
SummaryThis gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for PYCR1

Proteins

pyrroline-5-carboxylate reductase 1, mitochondrial isoform 1
Refseq ID:NP_008838
Protein GI:24797097
UniProt ID:P32322
mRNA ID:NM_006907
Length:319
RefSeq Status:
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVT
ISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRR
LAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL
SPSGHTKLLPRSLAPAGKD
 
pyrroline-5-carboxylate reductase 1, mitochondrial isoform 1
Refseq ID:NP_001269209
Protein GI:533112488
UniProt ID:P32322
mRNA ID:NM_001282280
Length:319
RefSeq Status:
Protein sequence is identical to GI:24797097 (mRNA isoform)
 
pyrroline-5-carboxylate reductase 1, mitochondrial isoform 2
Refseq ID:NP_722546
Protein GI:24797095
UniProt ID:P32322
mRNA ID:NM_153824
Length:316
RefSeq Status:
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVT
ISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRR
LAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKDHLPLELGSPE
GLHPLLLQYQLARAPS
 
pyrroline-5-carboxylate reductase 1, mitochondrial isoform 3
Refseq ID:NP_001269208
Protein GI:533112486
UniProt ID:E2QRB3
mRNA ID:NM_001282279
Length:288
RefSeq Status:
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVT
ISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYGAAKMLLHSEQHPGQLKDNV
SSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
 
pyrroline-5-carboxylate reductase 1, mitochondrial isoform 5
Refseq ID:NP_001269210
Protein GI:533112491
UniProt ID:P32322
mRNA ID:NM_001282281
Length:346
RefSeq Status:
MVGGGRRVGRDEPVPSVGALGQGSPDSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPH
IIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGL
SGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMAD
QEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
 
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