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MGP002562

Record overview

MGPD IDMGP002562
Gene ID5883
SpeciesHomo sapiens (Human)
Gene NameRAD9 homolog A (S. pombe)
Gene Symbol RAD9A
SynonymsRAD9;
Alternate namescell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD9;
Chromosome11
Map Location11q13.1-q13.2
EC Number3.1.11.2
SummaryThis gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for RAD9A

Proteins

cell cycle checkpoint control protein RAD9A isoform 1
Refseq ID:NP_004575
Protein GI:4759022
UniProt ID:Q99638
mRNA ID:NM_004584
Length:391
RefSeq Status:
MKCLVTGGNVKVLGKAVHSLSRIGDELYLEPLEDGLSLRTVNSSRSAYACFLFAPLFFQQYQAATPGQDLLRCKILMKSFLSVFRSLAMLEKTVEKCCIS
LNGRSSRLVVQLHCKFGVRKTHNLSFQDCESLQAVFDPASCPHMLRAPARVLGEAVLPFSPALAEVTLGIGRGRRVILRSYHEEEADSTAKAMVTEMCLG
EEDFQQLQAQEGVAITFCLKEFRGLLSFAESANLNLSIHFDAPGRPAIFTIKDSLLDGHFVLATLSDTDSHSQDLGSPERHQPVPQLQAHSTPHPDDFAN
DDIDSYMIAMETTIGNEGSRVLPSISLSPGPQPPKSPGPHSEEEDEAEPSTVPGTPPPKKFRSLFFGSILAPVRSPQGPSPVLAEDSEGEG
 
cell cycle checkpoint control protein RAD9A isoform 2
Refseq ID:NP_001230153
Protein GI:342672046
UniProt ID:Q99638
mRNA ID:NM_001243224
Length:315
RefSeq Status:
MQSFLSVFRSLAMLEKTVEKCCISLNGRSSRLVVQLHCKFGVRKTHNLSFQDCESLQAVFDPASCPHMLRAPARVLGEAVLPFSPALAEVTLGIGRGRRV
ILRSYHEEEADSTAKAMVTEMCLGEEDFQQLQAQEGVAITFCLKEFRGLLSFAESANLNLSIHFDAPGRPAIFTIKDSLLDGHFVLATLSDTDSHSQDLG
SPERHQPVPQLQAHSTPHPDDFANDDIDSYMIAMETTIGNEGSRVLPSISLSPGPQPPKSPGPHSEEEDEAEPSTVPGTPPPKKFRSLFFGSILAPVRSP
QGPSPVLAEDSEGEG
 
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