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MGP002612

UniProt Annotations

Entry Information
Gene Namereplication factor C (activator 1) 1, 145kDa
Protein EntryRFC1_HUMAN
UniProt IDP35251
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35251-1; Sequence=Displayed; Name=2; IsoId=P35251-2; Sequence=VSP_008443; Note=Alternative use of an acceptor site.;
FunctionInteracts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair. {ECO:0000269|PubMed:8999859}.
FunctionThe elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859}.
InteractionP35250:RFC2; NbExp=4; IntAct=EBI-476616, EBI-476409;
SimilarityBelongs to the activator 1 large subunit family. {ECO:0000305}.
SimilarityContains 1 BRCT domain. {ECO:0000255|PROSITE- ProRule:PRU00033}.
Subcellular LocationNucleus.
SubunitHeterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. {ECO:0000269|PubMed:8999859}.
Tissue SpecificityWide tissue distribution. Undetectable in placental tissue.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rfc1/";
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