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MGP002616

Record overview

MGPD IDMGP002616
Gene ID5985
SpeciesHomo sapiens (Human)
Gene Namereplication factor C (activator 1) 5, 36.5kDa
Gene Symbol RFC5
SynonymsRFC36;
Alternate namesreplication factor C subunit 5; A1 36 kDa subunit; RF-C 36 kDa subunit; RFC, 36.5 kD subunit; replication factor C, 36-kDa subunit;
Chromosome12
Map Location12q24.23
SummaryThe elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]
OrthologsView orthologs and multiple alignments for RFC5

Proteins

replication factor C subunit 5 isoform 1
Refseq ID:NP_031396
Protein GI:6677723
UniProt ID:P40937
mRNA ID:NM_007370
Length:340
RefSeq Status:
METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDI
IRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISED
GMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIH
LLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA
 
replication factor C subunit 5 isoform 2
Refseq ID:NP_853556
Protein GI:194306567
UniProt ID:P40937
mRNA ID:NM_181578
Length:319
RefSeq Status:
MVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFKL
VILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQ
STNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQ
LSSLIAAFQVTRDLIVAEA
 
replication factor C subunit 5 isoform 3
Refseq ID:NP_001123584
Protein GI:194306569
UniProt ID:P40937
mRNA ID:NM_001130112
Length:255
RefSeq Status:
MVLELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPR
LEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIH
LFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA
 
replication factor C subunit 5 isoform 4
Refseq ID:NP_001193730
Protein GI:332164786
UniProt ID:Q59GW7
mRNA ID:NM_001206801
Length:337
RefSeq Status:
METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDI
IRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISED
GMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRKLKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLT
KMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA
 
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