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MGP002616

UniProt Annotations

Entry Information
Gene Namereplication factor C (activator 1) 5, 36.5kDa
Protein Entry
UniProt IDQ59GW7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40937-1; Sequence=Displayed; Name=2; IsoId=P40937-2; Sequence=VSP_043067; Note=No experimental confirmation available.;
FunctionThe elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. {ECO:0000269|PubMed:8999859}.
InteractionP35249:RFC4; NbExp=6; IntAct=EBI-712376, EBI-476655;
SimilarityBelongs to the activator 1 small subunits family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitHeterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. {ECO:0000269|PubMed:11572977, ECO:0000269|PubMed:8999859}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rfc5/";
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