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MGP002618

Record overview

MGPD IDMGP002618
Gene ID5996
SpeciesHomo sapiens (Human)
Gene Nameregulator of G-protein signaling 1
Gene Symbol RGS1
Synonyms1R20; BL34; IER1; IR20; HEL-S-87;
Alternate namesregulator of G-protein signaling 1; B-cell activation protein BL34; early response protein 1R20; epididymis secretory protein Li 87; immediate-early response 1, B-cell specific; regulator of G-protein signalling 1;
Chromosome1
Map Location1q31
SummaryThis gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RGS1

Proteins

regulator of G-protein signaling 1
Refseq ID:NP_002913
Protein GI:115387108
UniProt ID:Q08116
mRNA ID:NM_002922
Length:209
RefSeq Status:
MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFG
SFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLL
NDLQANSLK
 
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