MGP Database

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MGP002618

UniProt Annotations

Entry Information
Gene Nameregulator of G-protein signaling 1
Protein EntryRGS1_HUMAN
UniProt IDQ08116
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08116-1; Sequence=Displayed; Name=2; IsoId=Q08116-2; Sequence=VSP_036422;
FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
InductionIn response to several B-cell activation signals.
PtmCould be phosphorylated. Might be functionally regulated by protein kinase(s).
Sequence CautionSequence=AAB26289.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15510.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51826.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 RGS domain. {ECO:0000255|PROSITE- ProRule:PRU00171}.
Tissue SpecificityB-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
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