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MGP002622

Record overview

MGPD IDMGP002622
Gene ID6001
SpeciesHomo sapiens (Human)
Gene Nameregulator of G-protein signaling 10
Gene Symbol RGS10
Alternate namesregulator of G-protein signaling 10; regulator of G-protein signalling 10;
Chromosome10
Map Location10q25
SummaryRegulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RGS10

Proteins

regulator of G-protein signaling 10 isoform a
Refseq ID:NP_001005339
Protein GI:52694755
UniProt ID:O43665
mRNA ID:NM_001005339
Length:181
RefSeq Status:
MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSS
KASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT
 
regulator of G-protein signaling 10 isoform b
Refseq ID:NP_002916
Protein GI:4506505
UniProt ID:O43665
mRNA ID:NM_002925
Length:167
RefSeq Status:
MEHIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRL
NEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT
 
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