MGP Database

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MGP002622

UniProt Annotations

Entry Information
Gene Nameregulator of G-protein signaling 10
Protein EntryRGS10_HUMAN
UniProt IDO43665
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O43665-1; Sequence=Displayed; Name=2; IsoId=O43665-2; Sequence=VSP_005681; Name=3; IsoId=O43665-3; Sequence=VSP_027366;
FunctionInhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.
PtmIsoform 3 is phosphorylated on Ser-16.
SimilarityContains 1 RGS domain. {ECO:0000255|PROSITE- ProRule:PRU00171}.
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