MGP Database

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MGP002701

Ontology/Pathway Information

Entrez Gene ID6196
Gene Nameribosomal protein S6 kinase, 90kDa, polypeptide 2
Gene Symbol RPS6KA2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0031965 IDA:HPACnuclear membrane
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005819 IEA:EnsemblCspindle
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0000287 IEA:InterProFmagnesium ion binding
GO:0004674 TAS:ProtIncFprotein serine/threonine kinase activity
GO:0004712 IDA:MGIFprotein serine/threonine/tyrosine kinase activity
GO:0004711 IEA:EnsemblFribosomal protein S6 kinase activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0002035 IEA:EnsemblPbrain renin-angiotensin system
GO:0010659 IEA:EnsemblPcardiac muscle cell apoptotic process
GO:0071322 IEA:EnsemblPcellular response to carbohydrate stimulus
GO:0060047 IEA:EnsemblPheart contraction
GO:0007507 IEA:EnsemblPheart development
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 TAS:ProtIncPintracellular signal transduction
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0045786 IDA:UniProtKBPnegative regulation of cell cycle
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0045835 IEA:EnsemblPnegative regulation of meiosis
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001556 IEA:EnsemblPoocyte maturation
GO:0018105 IEA:EnsemblPpeptidyl-serine phosphorylation
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0070613 IEA:EnsemblPregulation of protein processing
GO:0007165 NAS:ProtIncPsignal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_18266Axon guidance
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_12524CREB phosphorylation
REACT_20568CREB phosphorylation through the activation of Ras
REACT_111045Developmental Biology
REACT_12599ERK/MAPK targets
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22205L1CAM interactions
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_20593Post NMDA receptor activation events
REACT_22365Recycling pathway of L1
REACT_20510RSK activation
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_14797Signaling by GPCR
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_13477Transmission across Chemical Synapses
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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