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MGP002701

UniProt Annotations

Entry Information
Gene Nameribosomal protein S6 kinase, 90kDa, polypeptide 2
Protein EntryKS6A2_HUMAN
UniProt IDQ15349
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15349-1; Sequence=Displayed; Name=2; IsoId=Q15349-2; Sequence=VSP_017732; Note=No experimental confirmation available.; Name=3; IsoId=Q15349-3; Sequence=VSP_041836; Note=Ref.3 (BAG53121) sequence is in conflict in positions: 32:E->G, 34:T->A. {ECO:0000305};
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationUpon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD. {ECO:0000269|PubMed:10480933}.
FunctionSerine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
InteractionP15056:BRAF; NbExp=2; IntAct=EBI-1384149, EBI-365980; P27361:MAPK3; NbExp=2; IntAct=EBI-1384149, EBI-73995; Q02156:PRKCE; NbExp=2; IntAct=EBI-1384149, EBI-706254;
PtmActivated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity). {ECO:0000250}.
PtmN-terminal myristoylation results in an activated kinase in the absence of added growth factors. {ECO:0000250}.
Sequence CautionSequence=AAC82496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92353.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53121.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};
SimilarityBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. {ECO:0000305}.
SimilarityContains 1 AGC-kinase C-terminal domain. {ECO:0000305}.
SimilarityContains 2 protein kinase domains. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationNucleus {ECO:0000269|PubMed:7623830}. Cytoplasm {ECO:0000269|PubMed:7623830}.
SubunitForms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). {ECO:0000250}.
Tissue SpecificityWidely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
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