MGP Database

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MGP002731

Ontology/Pathway Information

Entrez Gene ID6241
Gene Nameribonucleotide reductase M2
Gene Symbol RRM2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004748 ISS:UniProtKBFribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0009186 IEA:InterProPdeoxyribonucleoside diphosphate metabolic process
GO:0009263 ISS:UniProtKBPdeoxyribonucleotide biosynthetic process
GO:0006260 IEA:UniProtKB-UniPathwayPDNA replication
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0015949 TAS:ReactomePnucleobase-containing small molecule interconversion
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0051290 IEA:EnsemblPprotein heterotetramerization
GO:0000083 TAS:ReactomePregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_471E2F mediated regulation of DNA replication
REACT_683G1/S-Specific Transcription
REACT_1783G1/S Transition
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_21267Mitotic G1-G1/S phases
REACT_21330Synthesis and interconversion of nucleotide di- and triphosphates
SMP Pathway Links
SMP IDDescription
SMP00535Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144Adenosine Deaminase Deficiency
SMP00167Adenylosuccinate Lyase Deficiency
SMP00168AICA-Ribosiduria
SMP00427Azathioprine Action Pathway
SMP00172Beta Ureidopropionase Deficiency
SMP00178Dihydropyrimidinase Deficiency
SMP00446Gemcitabine Action Pathway
SMP00603Gemcitabine Metabolism Pathway
SMP00365Gout or Kelley-Seegmiller Syndrome
SMP00364Lesch-Nyhan Syndrome (LNS)
SMP00428Mercaptopurine Action Pathway
SMP00536Mitochondrial DNA depletion syndrome
SMP00202MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
SMP00203Molybdenum Cofactor Deficiency
SMP00537Myoadenylate deaminase deficiency
SMP00050Purine Metabolism
SMP00210Purine Nucleoside Phosphorylase Deficiency
SMP00046Pyrimidine Metabolism
SMP00430Thioguanine Action Pathway
SMP00219UMP Synthase Deiciency (Orotic Aciduria)
SMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512Xanthinuria type I
SMP00513Xanthinuria type II
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