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MGP002731

UniProt Annotations

Entry Information
Gene Nameribonucleotide reductase M2
Protein EntryRIR2_HUMAN
UniProt IDP31350
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31350-1; Sequence=Displayed; Name=2; IsoId=P31350-2; Sequence=VSP_044917; Note=No experimental confirmation available. Ref.3 (DA477511) sequence is in conflict in positions: 28:R->H, 59:S->A. {ECO:0000305};
Catalytic Activity2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. {ECO:0000255|PROSITE-ProRule:PRU10014}.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250}; Note=Binds 2 iron ions per subunit. {ECO:0000250};
FunctionProvides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
InteractionP41002:CCNF; NbExp=12; IntAct=EBI-2339245, EBI-1207574; Q9UM11:FZR1; NbExp=2; IntAct=EBI-2339245, EBI-724997; P23921:RRM1; NbExp=3; IntAct=EBI-2339245, EBI-717006;
MiscellaneousTwo distinct regulatory sites have been defined: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2.
PathwayGenetic information processing; DNA replication.
PtmPhosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. {ECO:0000269|PubMed:16964243, ECO:0000269|PubMed:17693683, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}.
Sequence CautionSequence=DA477511; Type=Frameshift; Positions=87; Evidence={ECO:0000305};
SimilarityBelongs to the ribonucleoside diphosphate reductase small chain family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHeterodimer of a large and a small subunit.
Web ResourceName=Wikipedia; Note=Ribonucleotide reductase entry; URL="http://en.wikipedia.org/wiki/Ribonucleotide_reductase";
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