MGP Database

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MGP002743

Ontology/Pathway Information

Entrez Gene ID6283
Gene NameS100 calcium binding protein A12
Gene Symbol S100A12
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005856 TAS:UniProtKBCcytoskeleton
GO:0005829 TAS:UniProtKBCcytosol
GO:0005576 TAS:UniProtKBCextracellular region
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 TAS:UniProtKBCplasma membrane
GO:0005509 TAS:UniProtKBFcalcium ion binding
GO:0005507 TAS:UniProtKBFcopper ion binding
GO:0050786 IDA:UniProtKBFRAGE receptor binding
GO:0008270 TAS:UniProtKBFzinc ion binding
GO:0050663 TAS:UniProtKBPcytokine secretion
GO:0042742 TAS:UniProtKBPdefense response to bacterium
GO:0050832 IDA:UniProtKBPdefense response to fungus
GO:0006954 TAS:ProtIncPinflammatory response
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0031640 IEA:UniProtKB-KWPkilling of cells of other organism
GO:0045576 TAS:UniProtKBPmast cell activation
GO:0002548 TAS:UniProtKBPmonocyte chemotaxis
GO:0030593 TAS:UniProtKBPneutrophil chemotaxis
GO:0043123 IDA:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050729 TAS:UniProtKBPpositive regulation of inflammatory response
GO:0043406 TAS:UniProtKBPpositive regulation of MAP kinase activity
GO:0051092 TAS:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0006805 IDA:UniProtKBPxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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