MGP Database

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MGP002744

Ontology/Pathway Information

Entrez Gene ID6285
Gene NameS100 calcium binding protein B
Gene Symbol S100B
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IEA:EnsemblCextracellular space
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0001726 IDA:UniProtKBCruffle
GO:0048306 IDA:UniProtKBFcalcium-dependent protein binding
GO:0005509 NAS:UniProtKBFcalcium ion binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0050786 IPI:UniProtKBFRAGE receptor binding
GO:0044548 IPI:UniProtKBFS100 protein binding
GO:0048156 ISS:UniProtKBFtau protein binding
GO:0008270 ISS:UniProtKBFzinc ion binding
GO:0048708 IEA:EnsemblPastrocyte differentiation
GO:0007409 TAS:ProtIncPaxonogenesis
GO:0008283 TAS:ProtIncPcell proliferation
GO:0071456 IEA:EnsemblPcellular response to hypoxia
GO:0007417 TAS:ProtIncPcentral nervous system development
GO:0045087 TAS:ReactomePinnate immune response
GO:0007611 ISS:UniProtKBPlearning or memory
GO:0060291 IEA:EnsemblPlong-term synaptic potentiation
GO:0007613 IEA:EnsemblPmemory
GO:2001015 IEA:EnsemblPnegative regulation of skeletal muscle cell differentiation
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0043123 IDA:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0008360 IEA:EnsemblPregulation of cell shape
GO:0048168 IEA:EnsemblPregulation of neuronal synaptic plasticity
GO:0051384 IEA:EnsemblPresponse to glucocorticoid
GO:0051597 IEA:EnsemblPresponse to methylmercury
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_116022Nuclear signaling by ERBB4
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_115596Signaling by ERBB4
REACT_111102Signal Transduction
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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