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MGP002755

Record overview

MGPD IDMGP002755
Gene ID6324
SpeciesHomo sapiens (Human)
Gene Namesodium channel, voltage gated, type I beta subunit
Gene Symbol SCN1B
SynonymsATFB13; BRGDA5; GEFSP1;
Alternate namessodium channel subunit beta-1; sodium channel beta-1 subunit; sodium channel, voltage-gated, type I, beta subunit;
Chromosome19
Map Location19q13.1
SummaryVoltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for SCN1B

Proteins

sodium channel subunit beta-1 isoform a precursor
Refseq ID:NP_001028
Protein GI:4506805
UniProt ID:Q07699
mRNA ID:NM_001037
Length:218
RefSeq Status:
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKD
LQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEY
LAITSESKENCTGVQVAE
 
sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1788
peptide sequence: 
MGRLLALVVGAALVSSACG
 
sodium channel subunit beta-1 isoform b precursor
Refseq ID:NP_950238
Protein GI:39930610
UniProt ID:Q07699
mRNA ID:NM_199037
Length:268
RefSeq Status:
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKD
LQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPS
CPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVVLGLPGIIIRCVSRGVV
 
sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1788
peptide sequence: 
MGRLLALVVGAALVSSACG

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1788
peptide sequence: 
MGRLLALVVGAALVSSACG
 
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