MGP Database

MGP002774

Ontology/Pathway Information

Entrez Gene ID	6347
Gene Name	chemokine (C-C motif) ligand 2
Gene Symbol	CCL2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0043679	IEA:Ensembl	C	axon terminus
GO:0044299	IEA:Ensembl	C	C-fiber
GO:0030425	IEA:Ensembl	C	dendrite
GO:0030139	IEA:Ensembl	C	endocytic vesicle
GO:0005576	IDA:BHF-UCL	C	extracellular region
GO:0005615	TAS:ProtInc	C	extracellular space
GO:0043204	IEA:Ensembl	C	perikaryon
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0005791	IEA:Ensembl	C	rough endoplasmic reticulum
GO:0045202	IEA:Ensembl	C	synapse
GO:0031727	ISS:BHF-UCL	F	CCR2 chemokine receptor binding
GO:0008009	TAS:ProtInc	F	chemokine activity
GO:0008201	IEA:Ensembl	F	heparin binding
GO:0004672	TAS:ProtInc	F	protein kinase activity
GO:0005102	TAS:ProtInc	F	receptor binding
GO:0006987	TAS:Reactome	P	activation of signaling protein activity involved in unfolded protein response
GO:0007568	IEA:Ensembl	P	aging
GO:0001525	TAS:BHF-UCL	P	angiogenesis
GO:0043615	IDA:BHF-UCL	P	astrocyte cell migration
GO:0007155	TAS:ProtInc	P	cell adhesion
GO:0007166	TAS:ProtInc	P	cell surface receptor signaling pathway
GO:0006874	IEA:Ensembl	P	cellular calcium ion homeostasis
GO:0019725	TAS:BHF-UCL	P	cellular homeostasis
GO:0044267	TAS:Reactome	P	cellular protein metabolic process
GO:0071318	IEA:Ensembl	P	cellular response to ATP
GO:0071549	IEA:Ensembl	P	cellular response to dexamethasone stimulus
GO:0035690	IEA:Ensembl	P	cellular response to drug
GO:0044344	IEP:UniProtKB	P	cellular response to fibroblast growth factor stimulus
GO:0071403	IEA:Ensembl	P	cellular response to high density lipoprotein particle stimulus
GO:0032869	IEA:Ensembl	P	cellular response to insulin stimulus
GO:0071346	IEP:UniProtKB	P	cellular response to interferon-gamma
GO:0071347	IEP:UniProtKB	P	cellular response to interleukin-1
GO:0071354	IEA:Ensembl	P	cellular response to interleukin-6
GO:0071222	ISS:BHF-UCL	P	cellular response to lipopolysaccharide
GO:0036006	IEA:Ensembl	P	cellular response to macrophage colony-stimulating factor stimulus
GO:0071407	IDA:UniProtKB	P	cellular response to organic cyclic compound
GO:0036120	IEA:Ensembl	P	cellular response to platelet-derived growth factor stimulus
GO:0071300	IEA:Ensembl	P	cellular response to retinoic acid
GO:0071356	IEP:UniProtKB	P	cellular response to tumor necrosis factor
GO:0070098	IEA:Ensembl	P	chemokine-mediated signaling pathway
GO:0006935	TAS:ProtInc	P	chemotaxis
GO:0019221	IDA:BHF-UCL	P	cytokine-mediated signaling pathway
GO:0007010	IDA:UniProtKB	P	cytoskeleton organization
GO:0030968	TAS:Reactome	P	endoplasmic reticulum unfolded protein response
GO:0007186	TAS:ProtInc	P	G-protein coupled receptor signaling pathway
GO:0007187	TAS:ProtInc	P	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0035684	ISS:BHF-UCL	P	helper T cell extravasation
GO:0006959	TAS:ProtInc	P	humoral immune response
GO:0006954	IDA:UniProtKB	P	inflammatory response
GO:0007259	TAS:ProtInc	P	JAK-STAT cascade
GO:0002523	IEA:Ensembl	P	leukocyte migration involved in inflammatory response
GO:0031663	IDA:UniProtKB	P	lipopolysaccharide-mediated signaling pathway
GO:0048247	IEA:Ensembl	P	lymphocyte chemotaxis
GO:0048246	IDA:BHF-UCL	P	macrophage chemotaxis
GO:0000165	IMP:UniProtKB	P	MAPK cascade
GO:0060135	IEA:Ensembl	P	maternal process involved in female pregnancy
GO:0060137	IEA:Ensembl	P	maternal process involved in parturition
GO:0002548	IDA:BHF-UCL	P	monocyte chemotaxis
GO:0016525	IEA:Ensembl	P	negative regulation of angiogenesis
GO:0034351	IDA:UniProtKB	P	negative regulation of glial cell apoptotic process
GO:2000502	IDA:UniProtKB	P	negative regulation of natural killer cell chemotaxis
GO:0043524	IDA:UniProtKB	P	negative regulation of neuron apoptotic process
GO:0030593	IEA:Ensembl	P	neutrophil chemotaxis
GO:0009887	TAS:ProtInc	P	organ morphogenesis
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:2000427	ISS:BHF-UCL	P	positive regulation of apoptotic cell clearance
GO:0090280	IDA:BHF-UCL	P	positive regulation of calcium ion import
GO:0022409	IEA:Ensembl	P	positive regulation of cell-cell adhesion
GO:0002693	IEA:Ensembl	P	positive regulation of cellular extravasation
GO:0032967	IEA:Ensembl	P	positive regulation of collagen biosynthetic process
GO:0001938	IEA:Ensembl	P	positive regulation of endothelial cell proliferation
GO:0090265	IEA:Ensembl	P	positive regulation of immune complex clearance by monocytes and macrophages
GO:0001912	IEA:Ensembl	P	positive regulation of leukocyte mediated cytotoxicity
GO:0010759	IEA:Ensembl	P	positive regulation of macrophage chemotaxis
GO:0090026	IEA:Ensembl	P	positive regulation of monocyte chemotaxis
GO:0051770	ISS:BHF-UCL	P	positive regulation of nitric-oxide synthase biosynthetic process
GO:0050806	IEA:Ensembl	P	positive regulation of synaptic transmission
GO:0050870	ISS:BHF-UCL	P	positive regulation of T cell activation
GO:0032760	IEA:Ensembl	P	positive regulation of tumor necrosis factor production
GO:0043491	IMP:UniProtKB	P	protein kinase B signaling
GO:0006468	TAS:ProtInc	P	protein phosphorylation
GO:0008360	IDA:UniProtKB	P	regulation of cell shape
GO:0010574	IEA:Ensembl	P	regulation of vascular endothelial growth factor production
GO:0014823	IEA:Ensembl	P	response to activity
GO:0043200	IEA:Ensembl	P	response to amino acid
GO:0046677	IEA:Ensembl	P	response to antibiotic
GO:0009617	IEP:BHF-UCL	P	response to bacterium
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0010332	IEA:Ensembl	P	response to gamma radiation
GO:0009408	IEA:Ensembl	P	response to heat
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0009612	IEA:Ensembl	P	response to mechanical stimulus
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0033552	IEA:Ensembl	P	response to vitamin B3
GO:0009611	IEA:Ensembl	P	response to wounding
GO:0007165	NAS:ProtInc	P	signal transduction
GO:0007179	IEA:Ensembl	P	transforming growth factor beta receptor signaling pathway
GO:0048010	IEA:Ensembl	P	vascular endothelial growth factor receptor signaling pathway
GO:0019079	TAS:ProtInc	P	viral genome replication

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_18355	ATF4 activates genes
REACT_15344	Chemokine receptors bind chemokines
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_17015	Metabolism of proteins
REACT_14819	Peptide ligand-binding receptors
REACT_18277	PERK regulates gene expression
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction
REACT_18356	Unfolded Protein Response (UPR)