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MGP002774

UniProt Annotations

Entry Information
Gene Namechemokine (C-C motif) ligand 2
Protein EntryCCL2_HUMAN
UniProt IDP13500
SpeciesHuman
Comments
Comment typeDescription
FunctionChemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
InductionUp-regulated upon hypertonic conditions. {ECO:0000269|PubMed:23233732}.
PolymorphismGenetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].
PtmProcessing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
SimilarityBelongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitMonomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. {ECO:0000269|PubMed:8898111}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/scya2/";
Web ResourceName=Wikipedia; Note=CCL2 entry; URL="http://en.wikipedia.org/wiki/CCL2";
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