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MGP002783

Record overview

MGPD IDMGP002783
Gene ID6364
SpeciesHomo sapiens (Human)
Gene Namechemokine (C-C motif) ligand 20
Gene Symbol CCL20
SynonymsCKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha;
Alternate namesC-C motif chemokine 20; CC chemokine LARC; beta chemokine exodus-1; liver and activation-regulated chemokine; macrophage inflammatory protein 3 alpha; small inducible cytokine subfamily A (Cys-Cys), member 20; small-inducible cytokine A20;
Chromosome2
Map Location2q36.3
SummaryThis antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
OrthologsView orthologs and multiple alignments for CCL20

Proteins

C-C motif chemokine 20 isoform 1 precursor
Refseq ID:NP_004582
Protein GI:4759076
UniProt ID:P78556
mRNA ID:NM_004591
Length:96
RefSeq Status:
MCCTKSLLLAALMSVLLLHLCGESEAASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM
 
sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2750
peptide sequence: 
MCCTKSLLLAALMSVLLLHLCGESEA

mat_peptide: 27..95
product: C-C motif chemokine 20 isoform 2
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12949249]
calculated_mol_wt: 7959
peptide sequence: 
SNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM

sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2750
peptide sequence: 
MCCTKSLLLAALMSVLLLHLCGESEA

mat_peptide: 27..96
product: C-C motif chemokine 20 isoform 1
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12949249]
calculated_mol_wt: 8030
peptide sequence: 
ASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM
 
C-C motif chemokine 20 isoform 2 precursor
Refseq ID:NP_001123518
Protein GI:194239688
UniProt ID:P78556
mRNA ID:NM_001130046
Length:95
RefSeq Status:
MCCTKSLLLAALMSVLLLHLCGESEASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM
 
sig_peptide: 1..26
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2750
peptide sequence: 
MCCTKSLLLAALMSVLLLHLCGESEA

mat_peptide: 27..95
product: C-C motif chemokine 20 isoform 2
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12949249]
calculated_mol_wt: 7959
peptide sequence: 
SNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM
 
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