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MGP002783

UniProt Annotations

Entry Information
Gene Namechemokine (C-C motif) ligand 20
Protein EntryCCL20_HUMAN
UniProt IDP78556
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78556-1; Sequence=Displayed; Name=2; IsoId=P78556-2; Sequence=VSP_001061;
FunctionChemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. {ECO:0000269|PubMed:12149255}.
InductionBy bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U- 937 cell line and bowes melanoma. Repressed by IL10/interleukin- 10.
InteractionQ15311:RALBP1; NbExp=2; IntAct=EBI-3913209, EBI-749285;
PtmC-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes. {ECO:0000269|PubMed:11035086}.
SimilarityBelongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitBinds to and activate CCR6.
Tissue SpecificityExpressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Web ResourceName=Wikipedia; Note=CCL20 entry; URL="http://en.wikipedia.org/wiki/CCL20";
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