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MGP002790

Record overview

MGPD IDMGP002790
Gene ID6375
SpeciesHomo sapiens (Human)
Gene Namechemokine (C motif) ligand 1
Gene Symbol XCL1
SynonymsLTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a;
Alternate nameslymphotactin; SCM-1-alpha; XC chemokine ligand 1; c motif chemokine 1; cytokine SCM-1; lymphotaxin; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1;
Chromosome1
Map Location1q23
SummaryThis antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
OrthologsView orthologs and multiple alignments for XCL1

Proteins

lymphotactin precursor
Refseq ID:NP_002986
Protein GI:4506853
UniProt ID:P47992
mRNA ID:NM_002995
Length:114
RefSeq Status:
MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPT
GTQQSTNTAVTLTG
 
sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2263
peptide sequence: 
MRLLILALLGICSLTAYIVEG

mat_peptide: 22..114
product: lymphotactin
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12949249]
calculated_mol_wt: 10272
peptide sequence: 
VGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG
 
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