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MGP002791

UniProt Annotations

Entry Information
Gene Namechemokine (C-X3-C motif) ligand 1
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
FunctionThe soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269|PubMed:21829356}.
InductionBy TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells.
PtmA soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. {ECO:0000250}.
PtmO-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320}.
SimilarityBelongs to the intercrine delta family. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass type I membrane protein.
Subcellular LocationProcessed fractalkine: Secreted.
SubunitMonomer. Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1. {ECO:0000269|PubMed:21829356, ECO:0000269|PubMed:9931005}.
Tissue SpecificitySmall intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.
Web ResourceName=Wikipedia; Note=CX3CL1 entry; URL="http://en.wikipedia.org/wiki/CX3CL1";
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