MGP Database

MGP002792

Record overview

MGPD ID	MGP002792
Gene ID	6382
Species	Homo sapiens (Human)
Gene Name	syndecan 1
Gene Symbol	SDC1
Synonyms	SDC; CD138; SYND1; syndecan;
Alternate names	syndecan-1; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; syndecan proteoglycan 1;
Chromosome	2
Map Location	2p24.1
Summary	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for SDC1

Proteins

syndecan-1 precursor

Refseq ID:	NP_002988
Protein GI:	29568086
UniProt ID:	P18827
mRNA ID:	NM_002997
Length:	310
RefSeq Status:

`MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPK EGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHQASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQL PAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQ KPTKQEEFYA`

sig_peptide: 1..17
calculated_mol_wt: 1988
peptide sequence: 
MRRAALWLWLCALALSL

mat_peptide: 18..310
product: syndecan-1
calculated_mol_wt: 30507
peptide sequence: 
QPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAR
EQEATPRPRETTQLPTTHQASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSG
ENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA

syndecan-1 precursor

Refseq ID:	NP_001006947
Protein GI:	55749480
UniProt ID:	P18827
mRNA ID:	NM_001006946
Length:	310
RefSeq Status:

Protein sequence is identical to GI:29568086 (mRNA isoform)

sig_peptide: 1..17
calculated_mol_wt: 1988
peptide sequence: 
MRRAALWLWLCALALSL

mat_peptide: 18..310
product: syndecan-1
calculated_mol_wt: 30507
peptide sequence: 
QPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAR
EQEATPRPRETTQLPTTHQASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSG
ENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA

sig_peptide: 1..17
calculated_mol_wt: 1988
peptide sequence: 
MRRAALWLWLCALALSL

mat_peptide: 28..310
product: syndecan-1
calculated_mol_wt: 29488
peptide sequence: 
NLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRE
TTQLPTTHQASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEP
DRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA