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MGP002792

UniProt Annotations

Entry Information

Gene Name	syndecan 1
Protein Entry	SDC1_HUMAN
UniProt ID	P18827
Species	Human

Comments

Comment type	Description
Function	Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
Ptm	Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Similarity	Belongs to the syndecan proteoglycan family. {ECO:0000305}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
Subunit	Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). {ECO:0000269\|PubMed:16007225, ECO:0000269\|PubMed:23395182}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SDC1ID42223ch2p24.html";