MGP Database

MGP002796

Record overview

MGPD ID	MGP002796
Gene ID	6387
Species	Homo sapiens (Human)
Gene Name	chemokine (C-X-C motif) ligand 12
Gene Symbol	CXCL12
Synonyms	IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12;
Alternate names	stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor;
Chromosome	10
Map Location	10q11.1
Summary	This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Orthologs	View orthologs and multiple alignments for CXCL12

Proteins

stromal cell-derived factor 1 isoform 5 precursor

Refseq ID:	NP_001264919
Protein GI:	489406390
UniProt ID:	P48061
mRNA ID:	NM_001277990
Length:	103
RefSeq Status:

`MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHYCTCLIRVSFHGATPLTQGSWVLYSLSCAGGETGLREPGPMVSPRVESHQEGRLGVPGPVNL GKA`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..119
product: stromal cell-derived factor 1 isoform gamma
calculated_mol_wt: 11566
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKGRREEKVGKKEKIGKKKRQKKRKAAQKRKN

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..103
product: stromal cell-derived factor 1 isoform 5
calculated_mol_wt: 8864
peptide sequence: 
KPVSLSYRCPCRFFESHYCTCLIRVSFHGATPLTQGSWVLYSLSCAGGETGLREPGPMVSPRVESHQEGRLGVPGPVNLGKA

stromal cell-derived factor 1 isoform alpha precursor

Refseq ID:	NP_954637
Protein GI:	40316924
UniProt ID:	P48061
mRNA ID:	NM_199168
Length:	89
RefSeq Status:

`MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..119
product: stromal cell-derived factor 1 isoform gamma
calculated_mol_wt: 11566
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKGRREEKVGKKEKIGKKKRQKKRKAAQKRKN

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..103
product: stromal cell-derived factor 1 isoform 5
calculated_mol_wt: 8864
peptide sequence: 
KPVSLSYRCPCRFFESHYCTCLIRVSFHGATPLTQGSWVLYSLSCAGGETGLREPGPMVSPRVESHQEGRLGVPGPVNLGKA

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..140
product: stromal cell-derived factor 1 isoform delta
calculated_mol_wt: 13356
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNNLISAAPAGKRVIAGARALHPSPPRACPTARAL
CEIRLWPPPEWSWPSPGDV

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..89
product: stromal cell-derived factor 1 isoform alpha
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12949249]
calculated_mol_wt: 7963
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK

stromal cell-derived factor 1 isoform beta precursor

Refseq ID:	NP_000600
Protein GI:	10834988
UniProt ID:	P48061
mRNA ID:	NM_000609
Length:	93
RefSeq Status:

`MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..119
product: stromal cell-derived factor 1 isoform gamma
calculated_mol_wt: 11566
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKGRREEKVGKKEKIGKKKRQKKRKAAQKRKN

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..103
product: stromal cell-derived factor 1 isoform 5
calculated_mol_wt: 8864
peptide sequence: 
KPVSLSYRCPCRFFESHYCTCLIRVSFHGATPLTQGSWVLYSLSCAGGETGLREPGPMVSPRVESHQEGRLGVPGPVNLGKA

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..140
product: stromal cell-derived factor 1 isoform delta
calculated_mol_wt: 13356
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNNLISAAPAGKRVIAGARALHPSPPRACPTARAL
CEIRLWPPPEWSWPSPGDV

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..89
product: stromal cell-derived factor 1 isoform alpha
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12949249]
calculated_mol_wt: 7963
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..93
product: stromal cell-derived factor 1 isoform beta
calculated_mol_wt: 8526
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM

stromal cell-derived factor 1 isoform delta precursor

Refseq ID:	NP_001171605
Protein GI:	296011023
UniProt ID:	P48061
mRNA ID:	NM_001178134
Length:	140
RefSeq Status:

`MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNNLISAAPAGKRV IAGARALHPSPPRACPTARALCEIRLWPPPEWSWPSPGDV`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..119
product: stromal cell-derived factor 1 isoform gamma
calculated_mol_wt: 11566
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKGRREEKVGKKEKIGKKKRQKKRKAAQKRKN

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..103
product: stromal cell-derived factor 1 isoform 5
calculated_mol_wt: 8864
peptide sequence: 
KPVSLSYRCPCRFFESHYCTCLIRVSFHGATPLTQGSWVLYSLSCAGGETGLREPGPMVSPRVESHQEGRLGVPGPVNLGKA

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..140
product: stromal cell-derived factor 1 isoform delta
calculated_mol_wt: 13356
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNNLISAAPAGKRVIAGARALHPSPPRACPTARAL
CEIRLWPPPEWSWPSPGDV

stromal cell-derived factor 1 isoform gamma precursor

Refseq ID:	NP_001029058
Protein GI:	76563933
UniProt ID:	P48061
mRNA ID:	NM_001033886
Length:	119
RefSeq Status:

`MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKGRREEKVGKKE KIGKKKRQKKRKAAQKRKN`

sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MNAKVVVVLVLVLTALCLSDG

mat_peptide: 22..119
product: stromal cell-derived factor 1 isoform gamma
calculated_mol_wt: 11566
peptide sequence: 
KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKGRREEKVGKKEKIGKKKRQKKRKAAQKRKN