MGP Database

MGP002796

Ontology/Pathway Information

Entrez Gene ID	6387
Gene Name	chemokine (C-X-C motif) ligand 12
Gene Symbol	CXCL12
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IEA:UniProtKB-KW	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0008009	IDA:UniProtKB	F	chemokine activity
GO:0042379	IMP:UniProtKB	F	chemokine receptor binding
GO:0045236	IDA:BHF-UCL	F	CXCR chemokine receptor binding
GO:0005102	TAS:ProtInc	F	receptor binding
GO:0008344	IEA:Ensembl	P	adult locomotory behavior
GO:0001667	IEA:Ensembl	P	ameboidal-type cell migration
GO:0008015	TAS:ProtInc	P	blood circulation
GO:0007155	TAS:ProtInc	P	cell adhesion
GO:0060326	IDA:UniProtKB	P	cell chemotaxis
GO:0006874	TAS:ProtInc	P	cellular calcium ion homeostasis
GO:0070098	IDA:BHF-UCL	P	chemokine-mediated signaling pathway
GO:0006935	TAS:UniProtKB	P	chemotaxis
GO:0007281	IEA:Ensembl	P	germ cell development
GO:0008354	IEA:Ensembl	P	germ cell migration
GO:0007186	TAS:ProtInc	P	G-protein coupled receptor signaling pathway
GO:0006955	TAS:ProtInc	P	immune response
GO:0050930	IEA:Ensembl	P	induction of positive chemotaxis
GO:0008045	IEA:Ensembl	P	motor neuron axon guidance
GO:1902230	IDA:BHF-UCL	P	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000107	IDA:BHF-UCL	P	negative regulation of leukocyte apoptotic process
GO:1903237	IDA:UniProtKB	P	negative regulation of leukocyte tethering or rolling
GO:0001764	IEA:Ensembl	P	neuron migration
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0001569	IEA:Ensembl	P	patterning of blood vessels
GO:0048842	IEA:Ensembl	P	positive regulation of axon extension involved in axon guidance
GO:0090280	TAS:BHF-UCL	P	positive regulation of calcium ion import
GO:0045785	IDA:MGI	P	positive regulation of cell adhesion
GO:0033603	IEA:Ensembl	P	positive regulation of dopamine secretion
GO:0001938	IEA:Ensembl	P	positive regulation of endothelial cell proliferation
GO:0090026	IDA:UniProtKB	P	positive regulation of monocyte chemotaxis
GO:2000406	IDA:MGI	P	positive regulation of T cell migration
GO:0008064	TAS:ProtInc	P	regulation of actin polymerization or depolymerization
GO:0009408	IEA:Ensembl	P	response to heat
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0009612	IEA:Ensembl	P	response to mechanical stimulus
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0009314	IEA:Ensembl	P	response to radiation
GO:0009615	TAS:ProtInc	P	response to virus
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0042098	IEA:Ensembl	P	T cell proliferation
GO:0022029	IEA:Ensembl	P	telencephalon cell migration

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_15344	Chemokine receptors bind chemokines
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_19231	G alpha (i) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_116022	Nuclear signaling by ERBB4
REACT_14819	Peptide ligand-binding receptors
REACT_115596	Signaling by ERBB4
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction