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MGP002808

Record overview

MGPD IDMGP002808
Gene ID6416
SpeciesHomo sapiens (Human)
Gene Namemitogen-activated protein kinase kinase 4
Gene Symbol MAP2K4
SynonymsJNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1;
Alternate namesdual specificity mitogen-activated protein kinase kinase 4; JNK-activated kinase 1; JNK-activating kinase 1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; SAPK/ERK kinase 1; c-Jun N-terminal kinase kinase 1; stress-activated protein kinase kinase 1;
Chromosome17
Map Location17p12
EC Number2.7.12.2
SummaryThis gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
OrthologsView orthologs and multiple alignments for MAP2K4

Proteins

dual specificity mitogen-activated protein kinase kinase 4 isoform 1
Refseq ID:NP_003001
Protein GI:4506889
UniProt ID:P45985
mRNA ID:NM_003010
Length:399
RefSeq Status:
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAE
DLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVI
PEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
 
dual specificity mitogen-activated protein kinase kinase 4 isoform 2
Refseq ID:NP_001268364
Protein GI:526479851
UniProt ID:P45985
mRNA ID:NM_001281435
Length:410
RefSeq Status:
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGFQINFCEKAQSKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKI
SPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFY
KYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSD
VWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMP
ATPSSPMYVD
 
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