MGP Database

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MGP002808

Ontology/Pathway Information

Entrez Gene ID6416
Gene Namemitogen-activated protein kinase kinase 4
Gene Symbol MAP2K4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IEA:EnsemblCaxon
GO:0005829 TAS:ReactomeCcytosol
GO:0032839 IEA:EnsemblCdendrite cytoplasm
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0043204 IEA:EnsemblCperikaryon
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008545 IEA:EnsemblFJUN kinase kinase activity
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IEA:UniProtKB-KWFprotein serine/threonine kinase activity
GO:0004713 IEA:UniProtKB-KWFprotein tyrosine kinase activity
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0061049 IEA:EnsemblPcell growth involved in cardiac muscle cell development
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0072709 IEA:EnsemblPcellular response to sorbitol
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0007254 TAS:ReactomePJNK cascade
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0045740 IEA:EnsemblPpositive regulation of DNA replication
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0051770 IEA:EnsemblPpositive regulation of nitric-oxide synthase biosynthetic process
GO:0007165 TAS:ProtIncPsignal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_75790Cytokine Signaling in Immune system
REACT_116125Disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22442Interleukin-1 signaling
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_21308MAP kinase activation in TLR cascade
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_169436Oxidative Stress Induced Senescence
REACT_22232Signaling by Interleukins
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264041Uptake and actions of bacterial toxins
REACT_264618Uptake and function of anthrax toxins
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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