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MGP002810

Record overview

MGPD IDMGP002810
Gene ID6422
SpeciesHomo sapiens (Human)
Gene Namesecreted frizzled-related protein 1
Gene Symbol SFRP1
SynonymsFRP; FRP1; FrzA; FRP-1; SARP2;
Alternate namessecreted frizzled-related protein 1; SARP-2; sFRP-1; secreted apoptosis-related protein 2;
Chromosome8
Map Location8p11.21
SummaryThis gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for SFRP1

Proteins

secreted frizzled-related protein 1 precursor
Refseq ID:NP_003003
Protein GI:56117838
UniProt ID:Q8N474
mRNA ID:NM_003012
Length:314
RefSeq Status:
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPL
LNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIE
HLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKK
MKNHECPTFQSVFK
 
sig_peptide: 1..31
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2865
peptide sequence: 
MGIGRSEGGRRGAALGVLLALGAALLAVGSA
 
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