MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002810

Ontology/Pathway Information

Entrez Gene ID6422
Gene Namesecreted frizzled-related protein 1
Gene Symbol SFRP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:UniProtKBCcell surface
GO:0005829 IDA:UniProtKBCcytosol
GO:0031012 IDA:BHF-UCLCextracellular matrix
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005622 IDA:UniProtKBCintracellular
GO:0005886 ISS:UniProtKBCplasma membrane
GO:0005578 IDA:BHF-UCLCproteinaceous extracellular matrix
GO:0004197 IMP:UniProtKBFcysteine-type endopeptidase activity
GO:0008144 IDA:UniProtKBFdrug binding
GO:0005109 IPI:UniProtKBFfrizzled binding
GO:0008201 IDA:UniProtKBFheparin binding
GO:0042802 IPI:BHF-UCLFidentical protein binding
GO:0017147 IPI:UniProtKBFWnt-protein binding
GO:0060346 IEA:EnsemblPbone trabecula formation
GO:0060070 IDA:BHF-UCLPcanonical Wnt signaling pathway
GO:0071773 IEP:UniProtKBPcellular response to BMP stimulus
GO:0071392 IEP:UniProtKBPcellular response to estradiol stimulus
GO:0071391 IDA:UniProtKBPcellular response to estrogen stimulus
GO:0044344 IDA:UniProtKBPcellular response to fibroblast growth factor stimulus
GO:0071363 IDA:UniProtKBPcellular response to growth factor stimulus
GO:0071504 IDA:UniProtKBPcellular response to heparin
GO:0071456 IEP:UniProtKBPcellular response to hypoxia
GO:0071347 IEP:UniProtKBPcellular response to interleukin-1
GO:0071380 IEP:UniProtKBPcellular response to prostaglandin E stimulus
GO:0009267 IEP:UniProtKBPcellular response to starvation
GO:0071560 IEP:UniProtKBPcellular response to transforming growth factor beta stimulus
GO:0071356 IDA:UniProtKBPcellular response to tumor necrosis factor
GO:0071305 IEP:UniProtKBPcellular response to vitamin D
GO:0071481 IEA:EnsemblPcellular response to X-ray
GO:0090246 IEA:EnsemblPconvergent extension involved in somitogenesis
GO:0048546 IEA:EnsemblPdigestive tract morphogenesis
GO:0009950 IDA:UniProtKBPdorsal/ventral axis specification
GO:0008585 IEA:EnsemblPfemale gonad development
GO:0002244 IDA:UniProtKBPhematopoietic progenitor cell differentiation
GO:0060218 IDA:UniProtKBPhematopoietic stem cell differentiation
GO:0008584 IEA:EnsemblPmale gonad development
GO:0022601 IEP:UniProtKBPmenstrual cycle phase
GO:0060766 IDA:UniProtKBPnegative regulation of androgen receptor signaling pathway
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0045578 IMP:UniProtKBPnegative regulation of B cell differentiation
GO:0030514 IEA:EnsemblPnegative regulation of BMP signaling pathway
GO:0046851 IMP:UniProtKBPnegative regulation of bone remodeling
GO:0090090 IDA:UniProtKBPnegative regulation of canonical Wnt signaling pathway
GO:2000080 IDA:UniProtKBPnegative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
GO:0030308 IDA:UniProtKBPnegative regulation of cell growth
GO:0030336 IDA:UniProtKBPnegative regulation of cell migration
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0050680 IDA:UniProtKBPnegative regulation of epithelial cell proliferation
GO:0010719 IDA:UniProtKBPnegative regulation of epithelial to mesenchymal transition
GO:2000270 IDA:UniProtKBPnegative regulation of fibroblast apoptotic process
GO:0048147 IDA:BHF-UCLPnegative regulation of fibroblast proliferation
GO:0010629 IDA:UniProtKBPnegative regulation of gene expression
GO:0046676 IDA:UniProtKBPnegative regulation of insulin secretion
GO:0043508 IEA:EnsemblPnegative regulation of JUN kinase activity
GO:0030279 IDA:UniProtKBPnegative regulation of ossification
GO:0045668 IEA:EnsemblPnegative regulation of osteoblast differentiation
GO:0033689 IMP:UniProtKBPnegative regulation of osteoblast proliferation
GO:0045671 IEA:EnsemblPnegative regulation of osteoclast differentiation
GO:0050732 IDA:UniProtKBPnegative regulation of peptidyl-tyrosine phosphorylation
GO:2000041 IEA:EnsemblPnegative regulation of planar cell polarity pathway involved in axis elongation
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0030178 IDA:UniProtKBPnegative regulation of Wnt signaling pathway
GO:2000054 IDA:UniProtKBPnegative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0014034 IEA:EnsemblPneural crest cell fate commitment
GO:0001843 IEA:EnsemblPneural tube closure
GO:0001649 IEP:UniProtKBPosteoblast differentiation
GO:0090179 IEA:EnsemblPplanar cell polarity pathway involved in neural tube closure
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0090263 IDA:UniProtKBPpositive regulation of canonical Wnt signaling pathway
GO:0030307 IDA:UniProtKBPpositive regulation of cell growth
GO:0001954 ISS:BHF-UCLPpositive regulation of cell-matrix adhesion
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:0050679 IMP:UniProtKBPpositive regulation of epithelial cell proliferation
GO:1902043 IDA:BHF-UCLPpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045600 IDA:UniProtKBPpositive regulation of fat cell differentiation
GO:2000271 IDA:UniProtKBPpositive regulation of fibroblast apoptotic process
GO:0051894 ISS:BHF-UCLPpositive regulation of focal adhesion assembly
GO:2000052 IDA:UniProtKBPpositive regulation of non-canonical Wnt signaling pathway
GO:0032855 ISS:BHF-UCLPpositive regulation of Rac GTPase activity
GO:0045880 IMP:UniProtKBPpositive regulation of smoothened signaling pathway
GO:0051496 ISS:BHF-UCLPpositive regulation of stress fiber assembly
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0030177 IDA:UniProtKBPpositive regulation of Wnt signaling pathway
GO:0060527 IEA:EnsemblPprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0006508 IMP:GOCPproteolysis
GO:0045765 ISS:BHF-UCLPregulation of angiogenesis
GO:0060687 IEA:EnsemblPregulation of branching involved in prostate gland morphogenesis
GO:0010564 IMP:UniProtKBPregulation of cell cycle process
GO:0042493 IDA:UniProtKBPresponse to drug
GO:0014070 IDA:UniProtKBPresponse to organic cyclic compound
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0044345 IEA:EnsemblPstromal-epithelial cell signaling involved in prostate gland development
GO:0001657 IEA:EnsemblPureteric bud development
GO:0090244 IEA:EnsemblPWnt signaling pathway involved in somitogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264383negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
  logo