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MGP002842

Ontology/Pathway Information

Entrez Gene ID6500
Gene NameS-phase kinase-associated protein 1
Gene Symbol SKP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031467 IDA:UniProtKBCCul7-RING ubiquitin ligase complex
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0019005 IDA:UniProtKBCSCF ubiquitin ligase complex
GO:0004842 IDA:UniProtKBFubiquitin-protein transferase activity
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000086 TAS:ReactomePG2/M transition of mitotic cell cycle
GO:0035518 IDA:UniProtKBPhistone H2A monoubiquitination
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0051437 TAS:ReactomePpositive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0016567 IDA:UniProtKBPprotein ubiquitination
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0031146 IDA:UniProtKBPSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0016032 TAS:ReactomePviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118656Activation of NF-kappaB in B cells
REACT_75774Adaptive Immune System
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_24941Circadian Clock
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_821Cyclin D associated events in G1
REACT_1574Cyclin E associated events during G1/S transition
REACT_75790Cytokine Signaling in Immune system
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_268156Degradation of GLI1 by the proteasome
REACT_267700Degradation of GLI2 by the proteasome
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_1590G1 Phase
REACT_1783G1/S Transition
REACT_2203G2/M Transition
REACT_268366GLI3 is processed to GLI3R by the proteasome
REACT_268323Hedgehog 'off' state
REACT_6185HIV Infection
REACT_6288Host Interactions of HIV factors
REACT_6900Immune System
REACT_22442Interleukin-1 signaling
REACT_160305Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_116022Nuclear signaling by ERBB4
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_115697Prolactin receptor signaling
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_21279Regulation of mitotic cell cycle
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_6821SCF-beta-TrCP mediated degradation of Emi1
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_115596Signaling by ERBB4
REACT_264508Signaling by Hedgehog
REACT_22232Signaling by Interleukins
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_899S Phase
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_9031Vpu mediated degradation of CD4
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