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MGP002844

Record overview

MGPD IDMGP002844
Gene ID6505
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Gene Symbol SLC1A1
SynonymsDCBXA; EAAC1; EAAT3; SCZD18;
Alternate namesexcitatory amino acid transporter 3; excitatory amino acid carrier 1; neuronal and epithelial glutamate transporter; sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 member 1;
Chromosome9
Map Location9p24
SummaryThis gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for SLC1A1

Proteins

excitatory amino acid transporter 3
Refseq ID:NP_004161
Protein GI:66773030
UniProt ID:P43005
mRNA ID:NM_004170
Length:524
RefSeq Status:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFC
TTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEY
KIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISIT
ATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTK
KSYVNGGFAVDKSDTISFTQTSQF
 
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