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MGP002855

UniProt Annotations

Entry Information
Gene Namesolute carrier family 2 (facilitated glucose transporter), member 4
Protein EntryGTR4_HUMAN
UniProt IDP14672
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14672-1; Sequence=Displayed; Name=2; IsoId=P14672-2; Sequence=VSP_056331, VSP_056332; Note=No experimental confirmation available.;
DiseaseDiabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:1521731, ECO:0000269|PubMed:1756912, ECO:0000269|PubMed:1918382}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
FunctionInsulin-regulated facilitative glucose transporter.
MiscellaneousInsulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation. {ECO:0000250}.
PtmSumoylated. {ECO:0000269|PubMed:11842083}.
SimilarityBelongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endomembrane system {ECO:0000269|PubMed:8300557}; Multi-pass membrane protein {ECO:0000269|PubMed:8300557}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8300557}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.
SubunitInteracts with NDUFA9 (By similarity). Binds to DAXX. Interacts via its N-terminus with SRFBP1. {ECO:0000250, ECO:0000269|PubMed:11842083, ECO:0000269|PubMed:16647043}.
Tissue SpecificitySkeletal and cardiac muscles; brown and white fat.
Web ResourceName=Wikipedia; Note=GLUT4 entry; URL="http://en.wikipedia.org/wiki/Glut4";
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