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MGP002868

Record overview

MGPD IDMGP002868
Gene ID6532
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 6 (neurotransmitter transporter), member 4
Gene Symbol SLC6A4
SynonymsHTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR;
Alternate namessodium-dependent serotonin transporter; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; Na+/Cl- dependent serotonin transporter; serotonin transporter 1; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4;
Chromosome17
Map Location17q11.2
SummaryThis gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SLC6A4

Proteins

sodium-dependent serotonin transporter
Refseq ID:NP_001036
Protein GI:4507043
UniProt ID:P31645
mRNA ID:NM_001045
Length:630
RefSeq Status:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLG
NVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSC
KNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKD
AGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPA
VLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
 
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